Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
We are back and happy. Nina had a subcarinal lymph node that had doubled in size by August. The brain lesion was slowly increasing in size for five years. In August we switched to systemic TDM-1 and continued the IT Herceptin with Topotecan. It appears we have put Nina into full remission. That is beyond anything we could have hoped for. Nina is the only alive of 288 patients with brain/spine HER+ involvement at MD Anderson in the period of 2008 to 2012. As far as we know, she is the only one without whole brain radiation where the disease has been put into remission in the United States. There is hope for success in this area and for a standardized treatment that actually works.
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