HER2 Support Group Forums - View Single Post - HER2+ and BRCA mutations

jaykay · 06-16-2014, 02:43 PM

Hi - sorry you are on this site but it is a great site with wonderful women and men!

I had Stage 1a bc 14 years ago (her2+,er+, pr-), lumpectomy, rads, anti-estrogen for 10 years (tamoxifen and femara). Herceptin/chemo was not recommended for early stage in 2000. I developed a new primary 12 years later - her2+, er+, pr_. Double mx, TCH x6 plus additional 11 Herceptin infusions, radiation and back on anti-estrogen.

I constantly wonder if chemo and Herceptin would have prevented the 2nd bc - I think so.

With your pathology plus the BRCA2+ - I'd go for whatever you can throw at the cancer now. That way, you know that you have done everything possible to fight the cancer

Best
Janis

06-16-2014, 02:43 PM	#30
jaykay Senior Member Join Date: Oct 2012 Posts: 646	Re: HER2+ and BRCA mutations - 1 or 2? Hi - sorry you are on this site but it is a great site with wonderful women and men! I had Stage 1a bc 14 years ago (her2+,er+, pr-), lumpectomy, rads, anti-estrogen for 10 years (tamoxifen and femara). Herceptin/chemo was not recommended for early stage in 2000. I developed a new primary 12 years later - her2+, er+, pr_. Double mx, TCH x6 plus additional 11 Herceptin infusions, radiation and back on anti-estrogen. I constantly wonder if chemo and Herceptin would have prevented the 2nd bc - I think so. With your pathology plus the BRCA2+ - I'd go for whatever you can throw at the cancer now. That way, you know that you have done everything possible to fight the cancer Best Janis __________________ March, 2000: 48, Post menopausal (5 yrs HRT) Left breast, IDC 3mm/DCIS 1.6cm, ER+/PR-/Her2+++, mod differentiated, MIB low, lumpectomy, node neg via SNB, rads=33 Stage 1a June, 2000: Tamox 4.5 years,Femara for 5 years (end in Jan. 2010) Sept, 2012: 61, Via mamm, ultrasound, biopsy, right breast, 2.3cm tumor, ER+/PR-/Her2+++, poorly diff, KI67 60-70% BRCA 1 and 2 negative October, 2012: Bi Mast with tissue expanders, port placement Final Path: IDC 2.8cm, DCIS, 1/4 sentinal nodes positive (@#$%). Stage IIB Nov 29, 2012: Begin TCH/6x/every 3 wks, H for 1 year/every 3 weeks. March 14, 2013: Finished chemo April 9, 2013: Begin radiation 28x May 22, 2013: Finished rads June 1st, 2013: Started Aromasin for 5 yrs. July 15, 2013: Switched to Letrozole (Femara). Probably for the rest of my life October 16, 2013: Exchange surgery October 31, 2013: Finished Herceptin December 5, 2013: Port removed Glad this year is over!