Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Pretty interesting as TDM-1 has a molecule that might allow blood brain barrier penetration. It is not good for direct input into the cavity (though an Ommaya reservoir or lumbar puncture) but IV appears to have some benefit. The goal right now is to get IT Herceptin and Perjeta going in clinical trials.
We are on the edge of making this disease go into remission for many women. I just want to say that many of us in the industry want this to occur as soon as possible.
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