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littledute · 03-01-2014, 04:02 PM

I found this exciting news as this drug (psoralen) breaks through the inner core by disrupting DNA replication and causing cell death when activated by an energy source such as UV light.
“Cancer drugs can recognize HER2 receptors when they are outside of the cell, but they don’t recognize the truncated version inside the cell nucleus. They have shown that psoralen is effective in targeting this other form of HER2 that is resistant to current HER2-targeted therapies.” I hope they have some clinical trails soon! They need to figure out how to get the UV light to the inner core of the HER2 positive cancer cell!!!

03-01-2014, 04:02 PM	#6
littledute Member Join Date: Nov 2012 Posts: 23	Re: Psoralen and Her2 I found this exciting news as this drug (psoralen) breaks through the inner core by disrupting DNA replication and causing cell death when activated by an energy source such as UV light. “Cancer drugs can recognize HER2 receptors when they are outside of the cell, but they don’t recognize the truncated version inside the cell nucleus. They have shown that psoralen is effective in targeting this other form of HER2 that is resistant to current HER2-targeted therapies.” I hope they have some clinical trails soon! They need to figure out how to get the UV light to the inner core of the HER2 positive cancer cell!!!