Re: PREVENTION OF HER2+ breast cancer may lie in n-3 Polyunsaturated fatty acids
In a very artificial construct, implanting tumor cells into mice specially bred to transform the n6 fatty acids they were consuming in their diets into n3 fatty acids, the tumors they were able to grow prior to starting that diet totally disappeared.
When looking for what was responsible for the phenomenon they not only implicated the down regulation of her2 signalling by n3 fatty acids, but, confusingly to me, among other things, the upregulation of PGE3, a prostaglandin. As prostaglandins usually have the opposite effect, I will need to get the original article and read it piecemeal in order to understand this more fully.
Hope this helps!
PS humans cannot perform the same trick as these genetically altered mice, ie transforming the "bad"pufas to "good" pufas, as I understand it
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