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Old 09-15-2013, 02:37 AM   #4
michka
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Join Date: Feb 2007
Location: Paris, France
Posts: 858
Re: Lung Problems on Kadcyla?

Hi Amy.
a very little number of women did report a sort of lung inflammation with TDM1 (Kadcyla) and some had to stop. At my 5th or 6th round my scan showed a small zone like depolished glass on the top of both lungs. I had breathing problems. the doctors said it was not cancer and that they did not know what it was from. They also said that the incriminated zones were too small to explain my breathing problems. I continued the treatment and it did not worsen. Because of the breathing problem and the extreme fatigue, the dose was lowered after 10 rounds and the traces in the lungs went away and this before my dosage was lowered a second time after 18 rounds. I am happy the doctors did not stop me because TDM1 wiped out my numerous tumors.
Amy, I hope what the doctors see on the scans will stay small or go away also. It should be watched of course because some girls really had to stop.
I think you are right to try to continue since the results are encouraging.
I hope others will share their experience because we react all so differently.
Hugs, Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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