[Rolepaul]

Cat,
There is a rumor of a new clinical trial using Intrathecal Pertuzumab at relatively high dose. This is based on work with my wife, Nina, who had the same issue in the brain as you did. I can tell you that the IT Herceptin with Topotecan has kept her brain and spine issues under control for almost two years. She initially had a large tumor on the brain surface that was removed by surgery, followed with Cyber knife, then lapatinib and Xeloda. She had additional Cyber knife treatments, but it progressed into the spinal area. At that point, we took charge and started IT Herceptin and Toptecan through MD Anderson. The results have been very good. The MRI scans this weekend on the brain and spine show no evidence of disease, which agrees with the spinal fluid analysis. Keep the faith as wee are trying to get women like you into a large clinical study.
Paul