HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

evlin75 · 03-04-2013, 01:23 PM

Depocyt is what my daughter is receiving IT and it cannot be mixed with Herceptin. Dr wanted to take her off Herceptin, but I feel it still can work now since the ommaya is in place. Maybe the LP did not give good perfusion. The Depocyt can b given every two weeks and then even farther apart later. The reason we had to go to it, is there was much progression and we needed to have some immediate relief. No obstrutions yet and that is good. So she is getting the Herceptin on alternate weeks.
The Depocyt is caustic and tends to inflame the tissues so steroids are also used. My daughter did have quite a reaction with the first treatment and was hospitalized to get it under control. The doctor then ordered more coverage of the steroids.
A VERY difficult nd trecherous path but we still have hope of knocking this down.

03-04-2013, 01:23 PM	#128
evlin75 Senior Member Join Date: Sep 2007 Posts: 118	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase Depocyt is what my daughter is receiving IT and it cannot be mixed with Herceptin. Dr wanted to take her off Herceptin, but I feel it still can work now since the ommaya is in place. Maybe the LP did not give good perfusion. The Depocyt can b given every two weeks and then even farther apart later. The reason we had to go to it, is there was much progression and we needed to have some immediate relief. No obstrutions yet and that is good. So she is getting the Herceptin on alternate weeks. The Depocyt is caustic and tends to inflame the tissues so steroids are also used. My daughter did have quite a reaction with the first treatment and was hospitalized to get it under control. The doctor then ordered more coverage of the steroids. A VERY difficult nd trecherous path but we still have hope of knocking this down.