HER2 Support Group Forums - View Single Post - T DM-1 Approved !!

Joan M · 02-27-2013, 08:29 AM

Phil,

I also progressed on a taxane. When originally diagnosed as stage 2 in fall 2003, I had AC, T + H (off-label). I declined to go into the adjuvant Herceptin trial because I had 7+ nodes and didn't want to draw the arm without the antibody. But my onc gave me the drug anyway since it had already been approved for advanced bc.

Yes, perhaps, tdm-1 and docetaxel is a waste of time, but since the trial is already underway we'll get an idea of just how good tdm-1 is. Right now, t-dm1 is surpassing the taxane for PFS, but they're neck and neck on OS.

And even though I agree with Dr. Vogl's point about using a suboptimal combo in EMILIA, I wouldn't go to him either because as a metastatic patient I want options, regardless.

http://www.ncbi.nlm.nih.gov/pubmed/23382472

Joan

02-27-2013, 08:29 AM	#45
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: T DM-1 Approved !! Phil, I also progressed on a taxane. When originally diagnosed as stage 2 in fall 2003, I had AC, T + H (off-label). I declined to go into the adjuvant Herceptin trial because I had 7+ nodes and didn't want to draw the arm without the antibody. But my onc gave me the drug anyway since it had already been approved for advanced bc. Yes, perhaps, tdm-1 and docetaxel is a waste of time, but since the trial is already underway we'll get an idea of just how good tdm-1 is. Right now, t-dm1 is surpassing the taxane for PFS, but they're neck and neck on OS. And even though I agree with Dr. Vogl's point about using a suboptimal combo in EMILIA, I wouldn't go to him either because as a metastatic patient I want options, regardless. http://www.ncbi.nlm.nih.gov/pubmed/23382472 Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!