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rhondalea · 02-09-2013, 06:30 AM

And the verdict is: does not increase risk.

Link to abstract (and free downloadable PDF):

http://www.bmj.com/content/346/bmj.f165

Abstract
Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers.

Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake

Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer.

Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

02-09-2013, 06:30 AM	#1
rhondalea Senior Member Join Date: Jun 2011 Location: Somerset, NJ Posts: 487	Work stress and risk of cancer And the verdict is: does not increase risk. Link to abstract (and free downloadable PDF): http://www.bmj.com/content/346/bmj.f165 Abstract Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers. __________________ 2/6/09 Core needle biopsy: negative; Mammos through 2010: no change 3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much 4/14/11 Core needle biopsy: negative for cancer 5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5 6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3 7/14/11 CT/Bone scans NED; MUGA 66% 7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11 9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64% 9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012 12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy! 2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17 5/16/12 Start five-years Metformin trial 6/19/12 MUGA 61% 8/21/12 Brain MRI NED (head still hurts, brain still fogged) 9/4/12 Herceptin done! 9/6/12 Port out! 7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013 5/2014 Add Namenda 7mg 9/2014 Stop Aricept and Namenda; Neuropsychological evaluation 10/24/14 Start cognitive rehabilitation therapy