Re: TDM-1 side effects
I have been on the Marianne study - TDM-1 plus/minus pertuzumab since April 2011 - 22months. I think that puts me at about 30 doses. Overall, I've been very good on it - with no nausea, hair loss at all. The fatigue has become an issue, particularly since month 19. I also developed a blood disorder around month 3. It appeared as a "rash" which has been diagnosed as telangectasias (broken capillary vessels) all over my chest and hands and on my face as well. Also, I bleed very easily, like my blood is thin and doesn't clot well. They ran a whole series of tests that show that I do clot, but just not normally.
Since you asked, here are my abnormal lab results from my last draw on Monday - they have all been very stable throughout.
Hemoglobin 10.3
Hematocrit 31.5
RDW 18.9
%Monocytes 18.2
Albumin 3.8
ALT 82
AST 107
I hope that helps. Would love to hear from others who have bleeding issues or fatigue after a long time on TDM-1.
I have been NED since my very first scan after getting on the drug!
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Eva Sophia
Jun 08: stage IIb diagnosis at age 36
Jun-nov08: fec+taxol+ herceptin for one year
Dec08: lumpectomy and axillary lymph node dissection
Mar 09: radiation
Feb09-nov10: NED on tamoxifen and zometa every six months
Nov10: stage iv w 2 breast recur and mets to sternum and spine
Dec10: oopherectomy (ovary removal). Started femara
Jan11: cyberknife to spine and sternum
Apr 11: TDM-1plus minus pertuzumab Marianne study
June11: breast lumps gone. Bone activity way down.
Nov11: NED
Jan 13: Still in study. Dose reduce to 3.0 from 3.6
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