HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

evlin75 · 01-10-2013, 05:15 PM

I looked up the protocol at Sloan Kettering and it seems quite in line with the Chicago trial my daughter Susan was in for a short time.
Some get higher doses than others but go only to 40 mg.
The routine is usually 10 mg twice week for the first month.
The dose not large enough to work for my daughter even at 40, so she is being given 60. Higher doses seem to be needed to clear the meninges.

Thanks for the info. Getting clinical trials started though is progress.
Ev

01-10-2013, 05:15 PM	#104
evlin75 Senior Member Join Date: Sep 2007 Posts: 118	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase I looked up the protocol at Sloan Kettering and it seems quite in line with the Chicago trial my daughter Susan was in for a short time. Some get higher doses than others but go only to 40 mg. The routine is usually 10 mg twice week for the first month. The dose not large enough to work for my daughter even at 40, so she is being given 60. Higher doses seem to be needed to clear the meninges. Thanks for the info. Getting clinical trials started though is progress. Ev