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Mandamoo · 12-10-2012, 06:34 AM

Oh well I did suspect it wasn't doing much for me. Scans today seem to show progression. I haven't seen the report, I saw the films and suspected progression so rang my oncologist who spoke to the radiologist who confirmed it looks like progression - new spots and about 25% increase in size of existing spots. No new sites and apparently lymph nodes are stable which is surprising.

So... not even 4 months of stability on the "wonder drug". What next? Talking Pertuzamab, herceptin and Abraxane combo though I am wondering about DeenaH's combo of Avastin, Herceptin, Tykerb and Abraxane? I'm still asymptomatic and able to swim for an hour. I get tired but hell - I've had chemo for nearly 2 years continuously now so I guess that's a given.

Feeling bummed the "best" didn't work for me. Onto the next thing - maybe something will work.

12-10-2012, 06:34 AM	#1
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	TDM1 is bust for me Oh well I did suspect it wasn't doing much for me. Scans today seem to show progression. I haven't seen the report, I saw the films and suspected progression so rang my oncologist who spoke to the radiologist who confirmed it looks like progression - new spots and about 25% increase in size of existing spots. No new sites and apparently lymph nodes are stable which is surprising. So... not even 4 months of stability on the "wonder drug". What next? Talking Pertuzamab, herceptin and Abraxane combo though I am wondering about DeenaH's combo of Avastin, Herceptin, Tykerb and Abraxane? I'm still asymptomatic and able to swim for an hour. I get tired but hell - I've had chemo for nearly 2 years continuously now so I guess that's a given. Feeling bummed the "best" didn't work for me. Onto the next thing - maybe something will work. __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.