HER2 Support Group Forums - View Single Post - question about IT therapy using herceptin and topotecan

evlin75 · 11-07-2012, 12:40 PM

Daughter is being started on topotecan IT along with the Herceptin 40 mgs. Her latest MRI showed no change in the spinal leptomeningeal areas, but some signs of new brain involvement.
For those who have received this treatment, I ask about side effects. Will there be more problems with them?
She is on Tykerb and IV Herceptin besides the IT therapy. Also newly added Perjeta because of infected Ommaha port preventing systemic chemotherapy.
The Perjeta causes digestive upsets and loose stools that need to be controlled.
Daughter has lost weight from this but her tumor markers are now in the almost normal range.Just wondering what other side effects she might be facing with the topotecan.
Thanks for any input.

11-07-2012, 12:40 PM	#1
evlin75 Senior Member Join Date: Sep 2007 Posts: 118	question about IT therapy using herceptin and topotecan Daughter is being started on topotecan IT along with the Herceptin 40 mgs. Her latest MRI showed no change in the spinal leptomeningeal areas, but some signs of new brain involvement. For those who have received this treatment, I ask about side effects. Will there be more problems with them? She is on Tykerb and IV Herceptin besides the IT therapy. Also newly added Perjeta because of infected Ommaha port preventing systemic chemotherapy. The Perjeta causes digestive upsets and loose stools that need to be controlled. Daughter has lost weight from this but her tumor markers are now in the almost normal range.Just wondering what other side effects she might be facing with the topotecan. Thanks for any input.