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Sdgirl · 10-23-2012, 04:42 PM

All,
I was
dx with mets in Feb this year and have mets everywhere--brain, leptomenginal , liver, lungs and bone. I have tried Navelbine and Herceptin and progressed. Then tried Taxotere, Herceptin and perjetA and have progression again. I am debating what to next. Should I try Xeloda and tykerb or Halaven? I also have an option of doing the TDM1 EAP at a site that is a couple of hours away. I am not sure if I wll get in because of my untreated brain mets but have an appt set up. If perjeta failed, will TDM1 work? the perjeta combo worked great for six weeks and I went into remission but right after six weeks, it stopped working. My scans yesterday at 14 weeks should progression everywhere. Do you any advise or suggestions on what to do next? I feel like I am throwing darts in the dark and nothing will work anyway. I have lost faith after doing this for only 9 months.

10-23-2012, 04:42 PM	#1
Sdgirl Senior Member Join Date: Jun 2012 Location: San Diego Posts: 33	Pl help:Failed perjetA, now TDM1? All, I was dx with mets in Feb this year and have mets everywhere--brain, leptomenginal , liver, lungs and bone. I have tried Navelbine and Herceptin and progressed. Then tried Taxotere, Herceptin and perjetA and have progression again. I am debating what to next. Should I try Xeloda and tykerb or Halaven? I also have an option of doing the TDM1 EAP at a site that is a couple of hours away. I am not sure if I wll get in because of my untreated brain mets but have an appt set up. If perjeta failed, will TDM1 work? the perjeta combo worked great for six weeks and I went into remission but right after six weeks, it stopped working. My scans yesterday at 14 weeks should progression everywhere. Do you any advise or suggestions on what to do next? I feel like I am throwing darts in the dark and nothing will work anyway. I have lost faith after doing this for only 9 months.