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Old 09-26-2012, 11:49 AM   #13
bejuce
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Join Date: May 2009
Posts: 510
Re: Luminal B vs. HER-2 enriched?

Wow, thank you Lani and all of you trying to decipher the research for us! Looks like we still have a lot to learn about these subtypes. It seems to me that breaking down HER-2+ disease among two subtypes is premature as there may be many genetic differences between different HER-2+ tumors. At least that's the message that I'm getting with all this research. Hopefully it will translate into better and effective therapies for all breast cancers.

I still remember my shock when I was diagnosed and learned that the doctors had no way to tell (for the most part) which drugs to assign to each tumor. I thought that surely they would be able to tell from my biopsy which drugs to give. Targeted medicine still has long ways to go...
__________________
ER+ (30%)/PR-/HER-2+, stage 3

Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin


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