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Luminal B vs. HER-2 enriched?
Have you all seen the NYT and Nature articles on the 4 subtypes of breast cancer? It seems that they're classifying HER-2 enriched as ER-/PR-/HER-2+ and Luminal B as ER+ and/or PR+ and HER-2+.
I have not yet read the Nature article, but I'm wondering if there was any talk of prognosis differences between Luminal B and HER-2 enriched. Also, the Susan G. Komen website talks about this classification and says that HER-2 enriched benefits from Herceptin but they don't say that Luminal B benefits from it. Are Luminal B tumors usually not as responsive to Herceptin? Or is that something that the researchers are still working on to determine for sure? Lani, if you're reading this, can you please provide your insightful comments on the differences between Luminal B and HER-2 enriched?
Thanks!
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ER+ (30%)/PR-/HER-2+, stage 3
Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin
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