[Lani]

estrogen deficiency (the goal of AIs and perhaps the major mechanism of action of chemotherapy agents in premenopausal women with ER+ tumors) is well known to cause stiffness and associated joint pain

I have read on this site that asking that the benzoyl alcohol preservative be left out of any reconstitution (dilution) of a complete vial of herceptin relieved quite a few of joint complaints and stiffness. They cannot leave the preservative out of vials partially used as someone else uses them, they don't know how long until that additional portion will be used and the preservatives need to be in mix then.

Couldn't hurt to ask to try this. As I said, quite a few here noted leaving this preservative out helped.

Hope this helps!