HER2 Support Group Forums - View Single Post - I strongly recommend you read this article (even if you have to struggle a bit)

Rolepaul · 06-24-2012, 03:22 PM

NVP-BKM120 was used at 50 mg/kg for the mice. For a 132 pound (60 kg) woman, this would scale to 3 gm per dose, four dose per week. I hope this is not too expensive and does not have any side effects at these doses. Also, it might be some time before it gets to clinical trials. TDM-1 and Pertuzumab are available for now, and these are good front line systems. If the new drug can be brought to market and is less expensive and has fewer side effects, this will be a great step forward. The mere fact that both a test model and a drug have made this progress should be inspirational for the people on this web, both the women with HER+, their family members, and their friends.

06-24-2012, 03:22 PM	#9
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 391	Re: I strongly recommend you read this article (even if you have to struggle a bit) NVP-BKM120 was used at 50 mg/kg for the mice. For a 132 pound (60 kg) woman, this would scale to 3 gm per dose, four dose per week. I hope this is not too expensive and does not have any side effects at these doses. Also, it might be some time before it gets to clinical trials. TDM-1 and Pertuzumab are available for now, and these are good front line systems. If the new drug can be brought to market and is less expensive and has fewer side effects, this will be a great step forward. The mere fact that both a test model and a drug have made this progress should be inspirational for the people on this web, both the women with HER+, their family members, and their friends.