Hi Nelly,
I was on TDM1 for a long time, and experienced many of the S/E you describe. Low platelets is probably the most common one. Many people (myself included) also have elevated LFT's. I'll comment below by line on my experience:
-migraine/headache in left temple (uncomfortable pressure inside head) -
Not exactly, but I did have mild headache/flulike symptoms 2-3 days after infusion.
-chest pressure
I did not experience this
-joint pain (mild) -
I did have this
-heavy and multiple periods (during 1st treatment)
I was post menopausal, so don't know
-blood work showed extreme elevation in liver enzymes (one wk/post treatment)
Whoa baby, yes I did. AST was off the chart, with ASL and ASP also elevated.
-low white cells and platelets
WBC not so much, but platelets yes
-shedding(very light but noticeable)
Well, I didn't NOTICE it
I also had, day 4 of my first infusion, pain at tumor site. I wonder, does the chest pressure seem like it might be that? I'd get that checked out if not.
Overall, in the grand scheme of things, TDM1 is NOT as easy as plain vanilla Herceptin, but is far far more tolerable than traditional chemos. Also to consider, if you are in the Pertuzumab arm there could be additional side effects.
Hang in there!