HER2 Support Group Forums - View Single Post - variation of the mutation between ER+ and ER- in Her2+

Hopeful · 02-22-2012, 07:39 AM

Here is a link to the paper from which the table in the above link was taken: http://www.biomedcentral.com/1471-2407/10/539

The researchers were trying to determine what the differences were between hormone positive Her2+ bc and hormone negative Her2+ bc. It appears there are a wealth of differences at the genetic level.

This is the take away for me:

"Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors. These genes are typically associated with the luminal subtype, suggesting that the ER+ ERBB2-amplified tumors could be a branch of the luminal tumors and could share the same progenitor."

Luminal tumors (ER+ Her2-) are normally lower grade, slower growing tumors with a good prognosis that respond to endocrine therapy. Maybe the low response to endocrine therapy sets the Her2+'s apart?

Hopeful

02-22-2012, 07:39 AM	#3
Hopeful Senior Member Join Date: Aug 2006 Posts: 3,380	Re: variation of the mutation between ER+ and ER- in Her2+ Here is a link to the paper from which the table in the above link was taken: http://www.biomedcentral.com/1471-2407/10/539 The researchers were trying to determine what the differences were between hormone positive Her2+ bc and hormone negative Her2+ bc. It appears there are a wealth of differences at the genetic level. This is the take away for me: "Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors. These genes are typically associated with the luminal subtype, suggesting that the ER+ ERBB2-amplified tumors could be a branch of the luminal tumors and could share the same progenitor." Luminal tumors (ER+ Her2-) are normally lower grade, slower growing tumors with a good prognosis that respond to endocrine therapy. Maybe the low response to endocrine therapy sets the Her2+'s apart? Hopeful