HER2 Support Group Forums - View Single Post - Tamoxifen, LHRH agonist, AI, oophorectomy??

Becky · 02-12-2012, 11:35 AM

I also want to add that in the "olden" days, they would know that a cancer was hormone positive but they did not know that it was also Her2+. So even though the Tamoxifen may have been doing its job, there was nothing to supress the Her2 receptor so that would make the cancer recur. At least the Tamoxifen and Herceptin combo prevents that so in reality, you do not need to make decisions until the Herceptin therapy is over as the Tamoxifen will take care of the hormone receptors and the Herceptin will take care of the Her2 receptors.

I think (imho) that olden day tumors were not necessarily resistant to Tamoxifen, its just that there were 2 devils to deal with and nothing was done about the Her2 so that just took over.

02-12-2012, 11:35 AM	#7
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Tamoxifen, LHRH agonist, AI, oophorectomy?? I also want to add that in the "olden" days, they would know that a cancer was hormone positive but they did not know that it was also Her2+. So even though the Tamoxifen may have been doing its job, there was nothing to supress the Her2 receptor so that would make the cancer recur. At least the Tamoxifen and Herceptin combo prevents that so in reality, you do not need to make decisions until the Herceptin therapy is over as the Tamoxifen will take care of the hormone receptors and the Herceptin will take care of the Her2 receptors. I think (imho) that olden day tumors were not necessarily resistant to Tamoxifen, its just that there were 2 devils to deal with and nothing was done about the Her2 so that just took over. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"