HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 01-26-2012, 12:02 PM

More evidence that Omega 6 linoleic acid has a potential role in the development and spread of breast and logically other cancers.

An explanation for 'Epithelial-mesenchymal-transition' can be found at this wiki link
http://en.wikipedia.org/wiki/Epithel...mal_transition

Cadherins are proteins a bit like living velcro that help keep cells anchored to each other. Vitamin D reportedly increases adhesion between cells. In contrast this paper suggests Omega 6 linoleic acid weakens them, which would tie in with other reading

Int J Biochem Cell Biol. 2011 Dec;43(12):1782-91. Epub 2011 Sep 16.
Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A.
Espinosa-Neira R, Mejia-Rangel J, Cortes-Reynosa P, Salazar EP.
Source

Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, San Pedro Zacatenco, Mexico, DF 07360, Mexico.
Abstract

Epidemiological studies and animal models suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Epithelial-mesenchymal-transition (EMT) is a process, by which epithelial cells are transdifferentiated to a mesenchymal state, and it has been implicated in cancer progression, including invasion and metastasis. Linoleic acid (LA) induces proliferation and invasion in breast cancer cells. However, the role of LA on the EMT process in human mammary epithelial cells remains to be studied. In the present study, we demonstrate that LA induces a transient down-regulation of E-cadherin expression, accompanied with an increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions. Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion. In summary, our findings demonstrate, for the first time, that LA promotes an EMT-like process in MCF10A human mammary epithelial cells.

01-26-2012, 12:02 PM	#364
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. More evidence that Omega 6 linoleic acid has a potential role in the development and spread of breast and logically other cancers. An explanation for 'Epithelial-mesenchymal-transition' can be found at this wiki link http://en.wikipedia.org/wiki/Epithel...mal_transition Cadherins are proteins a bit like living velcro that help keep cells anchored to each other. Vitamin D reportedly increases adhesion between cells. In contrast this paper suggests Omega 6 linoleic acid weakens them, which would tie in with other reading Int J Biochem Cell Biol. 2011 Dec;43(12):1782-91. Epub 2011 Sep 16. Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. Espinosa-Neira R, Mejia-Rangel J, Cortes-Reynosa P, Salazar EP. Source Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, San Pedro Zacatenco, Mexico, DF 07360, Mexico. Abstract Epidemiological studies and animal models suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Epithelial-mesenchymal-transition (EMT) is a process, by which epithelial cells are transdifferentiated to a mesenchymal state, and it has been implicated in cancer progression, including invasion and metastasis. Linoleic acid (LA) induces proliferation and invasion in breast cancer cells. However, the role of LA on the EMT process in human mammary epithelial cells remains to be studied. In the present study, we demonstrate that LA induces a transient down-regulation of E-cadherin expression, accompanied with an increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions. Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion. In summary, our findings demonstrate, for the first time, that LA promotes an EMT-like process in MCF10A human mammary epithelial cells.