[chrisy]

Karen, I was on TDM1 as a single agent, no Taxol. So with the Taxol component it would definitely be a hair challenging event.
The intrahepatic chemo sounds promising, from what I know about it there is less general systemic toxicity because it is confined to the liver area.

TDM1 - With approval still likely to be a ways off, I'd be looking for a way to gain access to it in a trial. The chemo piece is not a taxane, so may outsmart that stupid tumor - plus give it the double whammy with the taxol. The other options you are considering would then be available to you if need them.

I know the hair thing IS a big deal. In the summer I was trying to get into a taxol-based trial and was researching "hair options" but not with glee. Still, we both know that if it is the best option it's worth it.

On the bone issue, I wonder why you would be getting an MRI rather than a bone scan...but I also remember getting a scan that noted "degenerative changes in bone" which had me freaking out until my oncologist reminded me that I was getting older, and that was the whole idea. Still, even if it is not suspicious for mets you probably should consider bone-strengthening meds in your total package. And definitely get it checked out so you know what you're dealing with.

On the positive side, it is a good thing to have several viable options on the table! You will make the right choice for you.