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Vicky · 11-30-2011, 03:39 PM

Karen,

I've been on T-DM1 for 7 months now. No hair loss. I am on the Marianne trial and along with T-DM1 I am either getting a placebo or Pertuzumab. It was my liver mets that completely disappeared after 3 cycles! They have not come back. The rest of my tumors did shrink a little and have since then remained stable. I have a numbing cream for my port Emla cream, and I do not feel the stick at all. The one time I forgot the cream they iced my port and I barely felt it at all. I couldn't tell you which port I have however, but its worked like a charm the entire time and the surgery to have it placed went very quickly and smoothly. I hope that helps with a couple of your questions. I've already been told Tykerb will more than likely be my next drug if I progress on T-DM1, so then I will have questions for you. Hang in there! You've survived so much already and I am in awe when I see your history! Hugs to you!

11-30-2011, 03:39 PM	#3
Vicky Senior Member Join Date: May 2011 Posts: 137	Re: Progression Confirmed And More Karen, I've been on T-DM1 for 7 months now. No hair loss. I am on the Marianne trial and along with T-DM1 I am either getting a placebo or Pertuzumab. It was my liver mets that completely disappeared after 3 cycles! They have not come back. The rest of my tumors did shrink a little and have since then remained stable. I have a numbing cream for my port Emla cream, and I do not feel the stick at all. The one time I forgot the cream they iced my port and I barely felt it at all. I couldn't tell you which port I have however, but its worked like a charm the entire time and the surgery to have it placed went very quickly and smoothly. I hope that helps with a couple of your questions. I've already been told Tykerb will more than likely be my next drug if I progress on T-DM1, so then I will have questions for you. Hang in there! You've survived so much already and I am in awe when I see your history! Hugs to you! __________________ 3-16-11 dx IDC 4.4 cm tumor, right breast,HER-2 neu 3+++, Stage III 3-25-11 PET scan shows 3 mets to liver and 1 to spine, Stage IV 4-12-11 start clinical trial of TDM1 infusion 1x every 3 weeks. 6-14-11 CT scan after 3 cycles shows NO liver spots, reduced spinal met from 18mm to 13mm and right breast mass from 4.4 to 4.2 cm. 8-12-11 Mastectomy rt. breast. 10-11 scans reflect stable cancer 12-11 MRI reveals area of concern in brain, CT scan reveals 3mm spot on lung. Watch and wait and rescan in a few weeks. Round 13 TDM1 complete. 2-21-12 Scans reveal progression in lungs with 4 new small mets. Officially off tdm1. Start halaven and radiation for single brain met, 1 spot in spine. 3-13 stereotactic radiosurgery for single brain met. 5-31-12 Halaven stopped due to low blood counts. Start tamoxifen and cont. Herceptin 1x3 weeks. 7-11-12- brain mri shows shrinking brain met and no new lesions. Cont. Herceptin and Tamoxifen 10-2-12 Stable tumor markers. Continue Herceptin and Tamoxifen 4-9-13 progression in lymph node under arm and new lung spots. Stop Tamoxifen. Add Xeloda to Herceptin. 6-10-13 Stereotactic radiosurgery to two new brain mets. Stop Xeloda due to lung mets progression. begin Tykerb 7-2-13. 10-29-13 Begin radiation to my lungs and one lymph node under my arm. Stop Tykerb until completion and then recommence. 1-31-14 Progression in lungs. Oophorectomy performed. 2-18-14 Begin Arimidex and continue Herceptin 7-7-15 progression with spots on colon, in pelvic region, and in lungs. Begin Taxotere, Perjeta and Herceptin. 11-15 Switch to weekly Taxol, and continue with Perjeta and Herceptin. 12-23-16 PET scan shows Complete Response with no new spots. Continue on with TPH indefinitely. 3-16-16 Still no evidence of disease, break from Taxol. Continue on with Perjeta and Herceptin.