HER2 Support Group Forums - View Single Post - another example of needing to find the right subgroup to determine drugs efficacy

AlaskaAngel · 11-18-2011, 09:32 AM

What it reminds me of that is quite specific to HER2 positive is the most obvious subgroup that still is waiting to be identified.... since the homework has never been done to find out if the group of early stage HER2 positive breast cancer has a BETTER outcome with trastuzumab used alone than with chemotherapy. At present this possibility continues to be just written off entirely.

Just think of how beneficial this could be in terms of people and resources if it ever saw the light of day.

AlaskaAngel

11-18-2011, 09:32 AM	#5
AlaskaAngel Senior Member Join Date: Sep 2005 Location: Alaska Posts: 2,018	Re: another example of needing to find the right subgroup to determine drugs efficacy What it reminds me of that is quite specific to HER2 positive is the most obvious subgroup that still is waiting to be identified.... since the homework has never been done to find out if the group of early stage HER2 positive breast cancer has a BETTER outcome with trastuzumab used alone than with chemotherapy. At present this possibility continues to be just written off entirely. Just think of how beneficial this could be in terms of people and resources if it ever saw the light of day. AlaskaAngel __________________ Dx 2002 age 51 bc for granny, aunt, cousin, sister, mother. ER+/PR+/HER2+++, grade 3 IDC 1.9 cm, some DCIS, Stage 1, Grade 3 Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen Rads necrosis BRCA 1 & 2 negative Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3 Exercise: 7 days a week, 1 hr/day No trastuzumab, no taxane, no AI NED