HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 10-07-2011, 03:26 PM

Hi All

Apologies I managed to duplicate a reference above.

The ongoing saga of dental infection continues, and my suspicion that dental infections can fog the brain remains. My childhood hockey accident broken root filled and refilled and apisectomied tooth [twice] appears to have been reinfecting the bone through escape of bacteria living in the space where the post sits - the tooth and a neighbouring tooth have now been removed - not a good look (-: - but hopefully the recurring infection in the bone in the area and likely higher in the face which has been going on to greater and lesser extent for several years, now may clear up.

This is a fascinating summary adding to the evidence excess linoleic acid (plant based 18 carbon Omega Six which makes up 50 - 70 % of the fat in many vegetable oils, and arguably which many of us get too much of) is a factor in BC.

Int J Biochem Cell Biol. 2011 Sep 16. [Epub ahead of print]
Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A.
Espinosa-Neira R, Mejia-Rangel J, Cortes-Reynosa P, Salazar EP.
Source

Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, San Pedro Zacatenco, Mexico, DF 07360, Mexico.
Abstract

Epidemiological studies and animal models suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Epithelial-mesenchymal-transition (EMT) is a process, by which epithelial cells are transdifferentiated to a mesenchymal state, and it has been implicated in cancer progression, including invasion and metastasis. Linoleic acid (LA) induces proliferation and invasion in breast cancer cells. However, the role of LA on the EMT process in human mammary epithelial cells remains to be studied. In the present study, we demonstrate that LA induces a transient down-regulation of E-cadherin expression, accompanied with an increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions. Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion. In summary, our findings demonstrate, for the first time, that LA promotes an EMT-like process in MCF10A human mammary epithelial cells.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21945809
[PubMed - as supplied by publisher]

10-07-2011, 03:26 PM	#351
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. Hi All Apologies I managed to duplicate a reference above. The ongoing saga of dental infection continues, and my suspicion that dental infections can fog the brain remains. My childhood hockey accident broken root filled and refilled and apisectomied tooth [twice] appears to have been reinfecting the bone through escape of bacteria living in the space where the post sits - the tooth and a neighbouring tooth have now been removed - not a good look (-: - but hopefully the recurring infection in the bone in the area and likely higher in the face which has been going on to greater and lesser extent for several years, now may clear up. This is a fascinating summary adding to the evidence excess linoleic acid (plant based 18 carbon Omega Six which makes up 50 - 70 % of the fat in many vegetable oils, and arguably which many of us get too much of) is a factor in BC. Int J Biochem Cell Biol. 2011 Sep 16. [Epub ahead of print] Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. Espinosa-Neira R, Mejia-Rangel J, Cortes-Reynosa P, Salazar EP. Source Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, San Pedro Zacatenco, Mexico, DF 07360, Mexico. Abstract Epidemiological studies and animal models suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Epithelial-mesenchymal-transition (EMT) is a process, by which epithelial cells are transdifferentiated to a mesenchymal state, and it has been implicated in cancer progression, including invasion and metastasis. Linoleic acid (LA) induces proliferation and invasion in breast cancer cells. However, the role of LA on the EMT process in human mammary epithelial cells remains to be studied. In the present study, we demonstrate that LA induces a transient down-regulation of E-cadherin expression, accompanied with an increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions. Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion. In summary, our findings demonstrate, for the first time, that LA promotes an EMT-like process in MCF10A human mammary epithelial cells. Copyright © 2011 Elsevier Ltd. All rights reserved. PMID: 21945809 [PubMed - as supplied by publisher] Last edited by R.B.; 10-07-2011 at 03:37 PM..