HER2 Support Group Forums - View Single Post - her2+ bc cured in mice with gamma secretase inhibitor(already developed vs Alzheimers

Lani · 07-22-2011, 04:16 AM

It didn't mention cure and it said the effect was reversible, but it also described long-term recurrence-free survival.

The gamma-secretase inhibitors are only in AD trials, and in one neoadjuvant her2+ bc trials.

A new paper by Dr. Yarden of Israel seems to imply a combination of herceptin and a gamma secretase inhibitor could stop ADH from progressing to DCIS and to her2+ bc.

More to come.

07-22-2011, 04:16 AM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: her2+ bc cured in mice with gamma secretase inhibitor(already developed vs Alzhei It didn't mention cure and it said the effect was reversible, but it also described long-term recurrence-free survival. The gamma-secretase inhibitors are only in AD trials, and in one neoadjuvant her2+ bc trials. A new paper by Dr. Yarden of Israel seems to imply a combination of herceptin and a gamma secretase inhibitor could stop ADH from progressing to DCIS and to her2+ bc. More to come.