HER2 Support Group Forums - View Single Post - Question about Zometa protocol/regimen. Any changes?

Chelee · 04-03-2011, 02:52 PM

Hi Vic,
Maybe your onc wants to ask if you would like to switch over to Denosumab? The report that came out from the last ASCO conference in Dec. 2010 said Zometa was a flop. Here's a link to it.

http://www.bloomberg.com/news/2010-12-09/novartis-to-withdraw-expanded-zometa-approval-request-after-trial-failure.html

Many onc are now asking their patients if they would like to try Denosumab which studies have said it's superior to Zometa. It's also not given by IV infusion..but rather a monthly subcutaneous injection which is more convenient. This may have nothing to do with why your onc wants to talk to you before your next infusion of Zometa--I'm just taking a wild quess since I was offered it along with many others I know of. Let us know what you find out? (Link below is about Denosumab if interested?)

http://www.pharmiweb.com/pressreleas...#ixzz1IUxrs6bh

Chelee

04-03-2011, 02:52 PM	#5
Chelee Senior Member Join Date: Feb 2006 Location: Southern, CA Posts: 2,511	Re: Question about Zometa protocol/regimen. Any changes? Hi Vic, Maybe your onc wants to ask if you would like to switch over to Denosumab? The report that came out from the last ASCO conference in Dec. 2010 said Zometa was a flop. Here's a link to it. http://www.bloomberg.com/news/2010-12-09/novartis-to-withdraw-expanded-zometa-approval-request-after-trial-failure.html Many onc are now asking their patients if they would like to try Denosumab which studies have said it's superior to Zometa. It's also not given by IV infusion..but rather a monthly subcutaneous injection which is more convenient. This may have nothing to do with why your onc wants to talk to you before your next infusion of Zometa--I'm just taking a wild quess since I was offered it along with many others I know of. Let us know what you find out? (Link below is about Denosumab if interested?) http://www.pharmiweb.com/pressreleas...#ixzz1IUxrs6bh Chelee __________________ DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes. Rt. MRM on 1-3-06 -- No Rads due to compromised lungs. Chemo started 2-7-06 -- TCH - - Finished 6-12-06 Finished yr of wkly herceptin 3-19-07 3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07 9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV. 9-28-09 Loading dose of Herceptin & started Zometa 9-29-09 Power Port Placement 10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head. 11-19-09 RT. Femur surgery - Rod placed 12-7-09 Navelbine added to Herceptin/Zometa. 3-23-10 Ten days of rads to RT femur. Completed. 4-05-10 Quit Navelbine--Herceptin/Zometa alone. 5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy. Results to FISH was unsuccessful--this happens less then 2% of the time. 7-7-10 Recurrence to RT axilla again. Back to UCLA for options.