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Lani · 02-04-2011, 10:56 PM

From Max Wicha's latest article(note the information on IL6):

Many human cancers, including breast cancer, may be driven by a population of cells that display stem cell properties. These properties include self-renewal, which drives tumorigenesis, and differentiation, which contributes to cancer cell heterogeneity. There is increasing evidence that these cancer stem cells (CSC) mediate tumor metastasis and, by virtue of their relative resistance to chemotherapy and radiation therapy, may contribute to treatment resistance and relapse following therapy (1).

Self-renewal and cell fate determination of normal stem cells are regulated by both cell intrinsic and cell extrinsic pathways. The dysregulation of these pathways resulting in stem cell expansion may be a key event initiating carcinogenesis. Developmental pathways such as Notch, Hedgehog, and Wnt play an important role in normal stem cell function and are frequently deranged in cancers (2–5). Extrinsic signals that regulate stem cell behavior originate in the stem cell microenvironment or niche. This niche contains extracellular components as well as multiple cell types.

Although there is little information on the composition and function of CSC niches, it is clear that tumor growth and metastasis is highly dependent on the tumor microenvironment. This microenvironment is composed of tumor-associated fibroblasts, endothelial cells, adipocytes, and immune cells, all of which have been shown to play a role in tumor growth and metastasis (6). Mesenchymal stem cells (MSC), which can be defined as multipotent mesenchymal stromal cells, are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues; proliferate as adherent cells; have fibroblast-like morphology; form colonies in vitro; and can differentiate into adipocytes, osteocytes, and chondrocytes (7). Recently, through the use of mouse breast cancer models, it has been shown that bone marrow–derived MSCs may be recruited to the sites of developing tumors, thus, influencing their metastatic potential (8). It has been shown that MSCs can produce IL6 (9, 10) and can stimulate tumor growth through the paracrine production of secreted IL6 (11). Both IL6 and IL8 have been implicated in the regulation of CSCs (12, 13).

WHY WOULD YOU WANT TO CHANCE STIMULATING YOUR TUMOR GROWTH or
"awakening and activating your dormant breast cancer stem cells in your bone marrow to cause them to divide, migrate and form macrometastases"
by producing more IL6 (246.5% more IL6 in the blood with bilateral knee replacement than with unilateral knee replacement)

Not trying to scare you, just hoping you will show moderation and do one knee at a time, giving you a leg to stand on as your shoulder won't be too much use holding you up and may not stand up to the strain of bearing all or part of your body weight.

Think before you leap!

02-04-2011, 10:56 PM	#16
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: Not cancer but a new challenge for me From Max Wicha's latest article(note the information on IL6): Many human cancers, including breast cancer, may be driven by a population of cells that display stem cell properties. These properties include self-renewal, which drives tumorigenesis, and differentiation, which contributes to cancer cell heterogeneity. There is increasing evidence that these cancer stem cells (CSC) mediate tumor metastasis and, by virtue of their relative resistance to chemotherapy and radiation therapy, may contribute to treatment resistance and relapse following therapy (1). Self-renewal and cell fate determination of normal stem cells are regulated by both cell intrinsic and cell extrinsic pathways. The dysregulation of these pathways resulting in stem cell expansion may be a key event initiating carcinogenesis. Developmental pathways such as Notch, Hedgehog, and Wnt play an important role in normal stem cell function and are frequently deranged in cancers (2–5). Extrinsic signals that regulate stem cell behavior originate in the stem cell microenvironment or niche. This niche contains extracellular components as well as multiple cell types. Although there is little information on the composition and function of CSC niches, it is clear that tumor growth and metastasis is highly dependent on the tumor microenvironment. This microenvironment is composed of tumor-associated fibroblasts, endothelial cells, adipocytes, and immune cells, all of which have been shown to play a role in tumor growth and metastasis (6). Mesenchymal stem cells (MSC), which can be defined as multipotent mesenchymal stromal cells, are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues; proliferate as adherent cells; have fibroblast-like morphology; form colonies in vitro; and can differentiate into adipocytes, osteocytes, and chondrocytes (7). Recently, through the use of mouse breast cancer models, it has been shown that bone marrow–derived MSCs may be recruited to the sites of developing tumors, thus, influencing their metastatic potential (8). It has been shown that MSCs can produce IL6 (9, 10) and can stimulate tumor growth through the paracrine production of secreted IL6 (11). Both IL6 and IL8 have been implicated in the regulation of CSCs (12, 13). WHY WOULD YOU WANT TO CHANCE STIMULATING YOUR TUMOR GROWTH or "awakening and activating your dormant breast cancer stem cells in your bone marrow to cause them to divide, migrate and form macrometastases" by producing more IL6 (246.5% more IL6 in the blood with bilateral knee replacement than with unilateral knee replacement) Not trying to scare you, just hoping you will show moderation and do one knee at a time, giving you a leg to stand on as your shoulder won't be too much use holding you up and may not stand up to the strain of bearing all or part of your body weight. Think before you leap!