Thread: Brain met trial
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Old 01-15-2011, 02:21 PM   #1
Joan M
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Brain met trial

I inquired with Dr. Black's office at Cedars-Sinai about a potential treatment for breast cancer brain metastases after reading an article in The New York Times about glioblastoma brain cancer which discussed treating this very deadly cancer with intrathecal chemotherapy. Dr. Black was cited in the article. A few years ago when I had my brain metastasis, I had read about a trial to treat breast cancer brain metastases with interathecal Herceptin. The trial was in Germany. At the time, I asked my neuro-oncologist about it, and he said he'd never heard of the trial. In any case, here's the response to my e-mail:

On behalf of Dr. Keith L. Black, Chairman of the Department of Neurosurgery at Cedars-Sinai Medical Center, I thank you for your inquiry and interest in our program. Thank you for sharing your history with us, and I’m very happy to learn you have been cancer free since October 2008. Dr. Black and Dr. Chirag Patil, our Director of the Center for Neurosurgical Outcomes Research, are developing a trial that would allow penetration of Herceptin into the metastatic brain tumors (from HER2+breast cancer). The study will likely open sometime next year – perhaps March 2011. Please feel free to check back with us next Spring as to the status and enrollment options.

In my initial e-mail I asked the doctor's office to put me on their mailing list for any trials that might become available for metastatic breast cancer brain tumors. Needless to say, I was totally surprised -- and happy about -- the response. I then asked for permission to post this information here, and they said it was okay. Dr. Black was one of the doctors quoted in the article which discussed only glioblastomas.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!

Last edited by Joan M; 01-15-2011 at 02:25 PM..
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