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chrisy · 08-31-2010, 05:50 PM

Well well my dear!

Oh yeah, I forgot that sometimes increasing tm's don't tell the whole story. Not progression is always a good thing!

Not sure what I would do next if it was me. Rich is right, the not eating window around Tykerb is important since it effectively increases the dose by slowing absorption.

I'd also think it's likely to be the combination of so many things causing the symptom...but then again it could have been something else entirely. I think there may be wisdom in starting slow and adding things one by one. That could include a lower dose of any of the drugs in the mix.

In the meantime I'll be holding thoughts of your body returning to it's "normal" from whatever this reaction is. If you can regain control of that, whatever you do will be easier.

Much love
Chris

08-31-2010, 05:50 PM	#5
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Re: PET/CT results good! next step? Well well my dear! Oh yeah, I forgot that sometimes increasing tm's don't tell the whole story. Not progression is always a good thing! Not sure what I would do next if it was me. Rich is right, the not eating window around Tykerb is important since it effectively increases the dose by slowing absorption. I'd also think it's likely to be the combination of so many things causing the symptom...but then again it could have been something else entirely. I think there may be wisdom in starting slow and adding things one by one. That could include a lower dose of any of the drugs in the mix. In the meantime I'll be holding thoughts of your body returning to it's "normal" from whatever this reaction is. If you can regain control of that, whatever you do will be easier. Much love Chris __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure