HER2 Support Group Forums - View Single Post - Genentech receives FDA Refuse to File Letter for T-DM1

chrisy · 08-27-2010, 07:35 PM

Unregistered guest: Right on.
Schoonder: Right on.
Barbara H: Right on.
Everyone else: Right on.
Nancy L: Right on - and I would add that during my stint on TDM1 I have been able to be a productive member of society, helped turn my company around thus continuing to keep 76 people in the workforce, paid boatloads of taxes, and chaperoned 3 preteen birthday parties - none of which would have been possible if I had been cycling through resource-depleting chemos instead of effective targeted therapy.

Also, I'd love to see the FDA in a smackdown with Dr. Slamon. I just dare them.

Brenda: ok you win, I am really pissed off now. I mean look at what just happened to my avatar. You're right, it's time to take off the kid gloves and put on the brass knuckles.

08-27-2010, 07:35 PM	#18
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Re: Genentech receives FDA Refuse to File Letter for T-DM1 Unregistered guest: Right on. Schoonder: Right on. Barbara H: Right on. Everyone else: Right on. Nancy L: Right on - and I would add that during my stint on TDM1 I have been able to be a productive member of society, helped turn my company around thus continuing to keep 76 people in the workforce, paid boatloads of taxes, and chaperoned 3 preteen birthday parties - none of which would have been possible if I had been cycling through resource-depleting chemos instead of effective targeted therapy. Also, I'd love to see the FDA in a smackdown with Dr. Slamon. I just dare them. Brenda: ok you win, I am really pissed off now. I mean look at what just happened to my avatar. You're right, it's time to take off the kid gloves and put on the brass knuckles. __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure