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Re: Xeloda/Tykerb
When I was on Herceptin and Tykerb, my fingers and toes would turn very red, get puffy, and bleed if I accidently bumped them. I had to see a poditrist twice for ingrown toe nails that got infected. My onc blamed the Tykerb for this. I used a heavy cream or vaseline on my hands and slept in white cotton gloves. This helped somewhat. After I finished, all this went away in a couple of weeks. I read somewhere that the theory behind this side effect is that the Tykerb settles in the furthest extremities and causes this. I took that to mean that even if I wasn't able to tolerate the full dose, my body had plenty of it in my system!
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Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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