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Re: Roll call, advice, TDM1?
Flori,
You've got a long list of cons there. Are you telling yourself this is not the trial for you?
As you know I'm a big fan of TDM1,and for me it has worked well as a single agent. But I'll try not to let that bias me too much.
That said, your concerns are valid - physically and emotionally out of your comfort zone is a big deal; going into a trial is a big commitment if you aren't really, well, committed.
Personally I'd love to be in a TDM1/Pertuzumab trial (I wouldn't be eligible though because of prior TDM1!). If you think that is a real possibility it might be worth holding out for that.
It seems like you really are doing quite well with your current scheme, as well as how you got there. A powerful synergy of your own wisdom and the right doors miraculously opening just when you are ready.
Go to your inside place (the wise one, not the screaming one) and listen to your heart. You will make the right choices.
Much love
Chris
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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