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Re: Roll call, advice, TDM1?
Flori,
I was traveling over the weekend and unable to reply to your post (my technology failed me).
I'm with Barbara H on the side effects - as well as speaking for the efficacy of TDM1. I think she meant she started in 2007 tho, not 1997  . I started in Feb 08 and am still dealing with the same side effects - low platelets, high liver enzymes, mild flu-like symptoms a day or so post infusion. But also, still able to get treatment, yank out the IV when it's done, and go do whatever!
It might just put the lights out, so to speak, on the sternum mets. Since they are active (albeit stable) you may qualify for the study. I hope so.
True, no indication that TDM1 would be protective of the brain - except as you said to shut down anything that might feel like wandering up there. With your long Tykerb run and stable elsewhere you're starting from a good place.
You wrote the original rap on this drug, I think it is time to give it a try if you can! Knowing you can go back to what has been holding things stable is a good fall back.
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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