[Lani]

1 rarebird--
What crosstalk are you referring to?

I have seen no papers indicating that blocking the her2 receptor via BOTH its internal and external domains(ie, what the combination of herceptin and tykerb does) does anything to block the development compensatory upregulation of ER, IGFR or other growth factor pathways via "crosstalk"

The fact that tykerb also should block her1 and her 4 via their internal domains and the fact that her3 does not have a phosphorylation site on its own internal domain theoretically should improve the blockade, but even the house studies found it necessary to add blocking of her3 via its external domain (pertuzumab) to block gowth

If you have literature showing this is the case, please post it as it would eliminate the need for panher blockers like pertuzumab, IGFR inhibitors, etc