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1rarebird · 05-23-2010, 05:37 PM

SoCal---Kathy and Barbara are so much more knowledgable about this than I am that I hesitate to add a comment. However, I have been reading quite a lot about the cross-talk phenonmon which occurs amoung the growth regulating recpetors (Her2 ane ER in particular). It has been recommended by more than one reseacher that blockading Her2 at both ends of the recepetor helps if not stops cross-talk and proliferation. Tykerb and Herceptin ( I believe TDM-1 too) should achieve this dual blockade. This is especially important with ER+ Her2+ cancers.

Good luck with you oncologist tomorrow.

bird

05-23-2010, 05:37 PM	#4
1rarebird Senior Member Join Date: Feb 2010 Location: TN Posts: 175	Re: Roll call, advice, TDM1? SoCal---Kathy and Barbara are so much more knowledgable about this than I am that I hesitate to add a comment. However, I have been reading quite a lot about the cross-talk phenonmon which occurs amoung the growth regulating recpetors (Her2 ane ER in particular). It has been recommended by more than one reseacher that blockading Her2 at both ends of the recepetor helps if not stops cross-talk and proliferation. Tykerb and Herceptin ( I believe TDM-1 too) should achieve this dual blockade. This is especially important with ER+ Her2+ cancers. Good luck with you oncologist tomorrow. bird __________________ Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.