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Old 05-12-2010, 07:56 AM   #8
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,778
Re: exciting preclinical finding re metformin (diabetes drug) killing cancer stem cel

Additionally:
The 6 ER+ breast cancer cell lines used were ZR-75-1
(6), MCF-7 (33), MDA-MB-134 (5), T-47D (14), BT-474 (15), and MDA- MB-361 (4). The ER- lines consisted of breast cancer lines, BT-20 (16), Hs0578T (10), MDA-MB-330 (4), and MDA-MB-231 , SkBr3

of those I believe only MDA-MB-361 and BT-474 are ER+ and SkBr3 and MDA-MB-453 are ER-(MB-453 has a lot of androgen receptors, however). I don't know about the JIMT-2 ie, whether they were ER+ or ER- before they grew them in such a way as to become herceptin resistant.

Hope this helps!
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