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Old 05-11-2010, 10:11 AM   #15
Rich66
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Join Date: Feb 2008
Location: South East Wisconsin
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Re: Pet Scan for Stage 1?

Although I thought ER was a clear minority of Her2+, recent bits suggest a 50/50 split:

Lapatinib plus Letrozole as First-Line Therapy for HER-2+ Hormone Receptor–Positive Metastatic Breast Cancer

Quote:
Approximately 50% of HER-2+ breast cancers are hormone receptor (HR)+, [4, 5, 7, 8] and HER-2 positivity is considered a marker of estrogen resistance [9, 10]. Therefore, dual treatment for tumors that overexpress both receptors is a logical approach.

for more on the Her2/ER crosstalk and ability of Her2+/ER- to turn ER+ after Her 2 therapy: HERE
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