Some oncs don't consider it but..there numerous
liver directed therapies.
I don't remember your pathology but...
A new biopsy could glean whether
hormonal therapies may be applicable. At the same time, you could have a sample analyzed for
chemo sensitivity to make more informed choices.
Chemos that failed before may work again...either because the break from a drug and/or mutation has made it pathologically more susceptible..or because an onc can try the same drugs with a different schedule..
metronomic or gompertzian. There are synergies in combinations with "failed" drugs that may work. And..of course...new drugs and new off label uses of existing drugs (eg.
metformin) and
integrative oncology keep the list of options growing.
My thought is if the list is short after 5 regimens, maybe the brain at the helm needs broadening.
($.02)