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Melissa · 02-24-2010, 03:22 PM

Thanks to everyone for the info. I guess we will have to wait for the head-to-head comparisons.

Yes, BonnieR, I agree. I was dumbstruck when the nurse said this to me. It made me feel as if she thinks I'm a whiner. I'm going to think on it, at least for a few days, before I respond to her. This is a weak area for me.

Karen - I'm not too logical but just because our cancer is Her2 does not mean that 100% of the cells are Her2. Some may only be PR or ER +. So maybe these cells didn't benefit from herceptin. Does this make sense? I think of it like a vein diagram, each cell may only have one marker or maybe some cells have all three markers. You can see from my history that my pathology report said 80% of my tumor was her2 so that made me wonder about the other 20%. By taking an AI I'm hoping to target any remaining cells that may be ER or PR +. And hoping herceptin targeted the her2's. At least this is what I tell myself.
Thanks again,

02-24-2010, 03:22 PM	#10
Melissa Senior Member Join Date: Jan 2008 Location: Virginia Posts: 116	Re: comparing AI'S Thanks to everyone for the info. I guess we will have to wait for the head-to-head comparisons. Yes, BonnieR, I agree. I was dumbstruck when the nurse said this to me. It made me feel as if she thinks I'm a whiner. I'm going to think on it, at least for a few days, before I respond to her. This is a weak area for me. Karen - I'm not too logical but just because our cancer is Her2 does not mean that 100% of the cells are Her2. Some may only be PR or ER +. So maybe these cells didn't benefit from herceptin. Does this make sense? I think of it like a vein diagram, each cell may only have one marker or maybe some cells have all three markers. You can see from my history that my pathology report said 80% of my tumor was her2 so that made me wonder about the other 20%. By taking an AI I'm hoping to target any remaining cells that may be ER or PR +. And hoping herceptin targeted the her2's. At least this is what I tell myself. Thanks again, __________________ Melissa 04/06, (42), 2cm tumor, 7/13 nodes, one positive node under clavicle mastectomy/reconstruction grade 3, stage lllb, er-65+, pr-90+, her2+++(80%) 4/AC, 12wks TH then 6wks rads 40 wks herceptin, and tamoxifen. onc test tamoxifen resistance = poor metabilizer 04/07 ooph & on arimidex 08/07 completed herceptin 04/2022 - 16 year survivor!