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Re: T-DM1 trials
I agree, it can't hurt to look into the other trials. You've already begun the taxol/herceptin, right?
So it's a choice between staying the course for another few cycles then switching to tykerb/xeloda; or trying to get into a TDM1 trial in the middle of your current treatment plan.
First, check out the details of the TDM1 trials - they have different inclusion/exclusion requirements (some require you have - or cannot have had - specific prior therapies), and also different designs (for example, one of the current phase III is tykerb/xeloda vs. TDM1.) Know what the options are first.
If you do qualify for a trial, there would probably be a washout period (no treatment at all) for a few weeks - which can be scary - and new baseline scans, which might answer the question if the taxol/herceptin is working.
There are no easy answers, the plan you are on seems a very reasonable option that could work really well...and so might other options!
Not too helpful, I know!!!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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