HER2 Support Group Forums - View Single Post

TSund · 01-05-2010, 09:27 AM

Question,

Has there been clear differentiation made on how the various AI's and tamoxifen target the various kinds of estrogen? In particular, targeting estradiol, which I believe is the most dangerous estrogen. While doing a google search I was shocked to see loads of body-building forums talking at great length about taking estrogen suppressing drugs; the exact same drugs bc patients take: tamoxifen, arimidex, aromasin, etc. While I know this is an EXTREMELY dubious souce of info, and I am appalled at what these people do for vanity, one post impied that aromasin was more effective at lowering estradiol than arimidex, which he/she claimed more targeted estrone. (these crazy people are doing bloodwork on a very frequent basis) I am interested if there is any scientific validity in this statement.

Thanks

TRS

01-05-2010, 09:27 AM	#1
TSund Senior Member Join Date: May 2007 Location: DFW area (TX) Posts: 431	AI's, etc effect on estradiol Question, Has there been clear differentiation made on how the various AI's and tamoxifen target the various kinds of estrogen? In particular, targeting estradiol, which I believe is the most dangerous estrogen. While doing a google search I was shocked to see loads of body-building forums talking at great length about taking estrogen suppressing drugs; the exact same drugs bc patients take: tamoxifen, arimidex, aromasin, etc. While I know this is an EXTREMELY dubious souce of info, and I am appalled at what these people do for vanity, one post impied that aromasin was more effective at lowering estradiol than arimidex, which he/she claimed more targeted estrone. (these crazy people are doing bloodwork on a very frequent basis) I am interested if there is any scientific validity in this statement. Thanks TRS __________________ Terri, spouse of Ruth, Dallas/Ft. Worth area Ruth dx 05/01/07 (age 50) Filipino multifocal, several tumors .5 -2.5 cm, large area Breast MRI showed 2 enlarged nodes, not palpable 100%ER+, 95%PR+, HER2+++ 6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage 1 year Herceptin till 6/08 MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells" now 50% ER+, PR- ??? Rads finished 1/16/08 Added Tamoxifen, Finished Herceptin 05/08 NOW is the time to appreciate life to the fullest.