HER2 Support Group Forums - View Single Post - getting her2+ER- bc to reexpress ER & consequences more complicated than thought

Becky · 01-02-2010, 08:02 AM

This is what I think this says. There are 2 bc cell lines used in this study that are ER negative lines - one of these lines is Her2+ and EGFR (aka Her1+). Using a virus, they put in a genetic component that made the cell line also ER+ (ERAlpha - this is the main ER+ marker there is also an ERBeta which isn't as "strong"). When the ER component was inserted, it immediately downgraded the cancer, slowed its growth and it began to not express the Her family as much. This happened because of certain pathways that ER+ cancer uses (all the other gobbldee goop).

01-02-2010, 08:02 AM	#5
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: getting her2+ER- bc to reexpress ER & consequences more complicated than thought This is what I think this says. There are 2 bc cell lines used in this study that are ER negative lines - one of these lines is Her2+ and EGFR (aka Her1+). Using a virus, they put in a genetic component that made the cell line also ER+ (ERAlpha - this is the main ER+ marker there is also an ERBeta which isn't as "strong"). When the ER component was inserted, it immediately downgraded the cancer, slowed its growth and it began to not express the Her family as much. This happened because of certain pathways that ER+ cancer uses (all the other gobbldee goop). __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"