HER2 Support Group Forums - View Single Post - NYTimes New technique to temporarily breach the blood-brain barrier,deliver avastin

Lani · 11-18-2009, 01:03 AM

mannitol exploits differences in osmotic pressure to pry open the tight spaces between the endothelial cells which make up the blood-brain barrier, THEN large molecules like avastin can go through

the rebound effect after avastin is something altogether different with a different mechanism(s) of action it seems

There are other occurences which make the BBB more permeable and lots still not understood

11-18-2009, 01:03 AM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: NYTimes New technique to temporarily breach the blood-brain barrier,deliver avas mannitol exploits differences in osmotic pressure to pry open the tight spaces between the endothelial cells which make up the blood-brain barrier, THEN large molecules like avastin can go through the rebound effect after avastin is something altogether different with a different mechanism(s) of action it seems There are other occurences which make the BBB more permeable and lots still not understood