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Rich66 · 11-15-2009, 01:18 PM

Autophagy. 2009 Nov 18;5(8). [Epub ahead of print]
Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies.

Grandér D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T.
Department of Oncology/Pathology, Cancer Centre Karolinska (CCK) R8:03, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. We have recently shown that dexamethasone induces autophagy in lymphoid leukemia cells and in this particular setting this cell death modality is a prerequisite for the efficient killing of the leukemic cells by dexamethasone.(1) Hence, inhibition of autophagy by siRNA-mediated silencing of Beclin 1, as well as chemical inhibition of type III PtdIns3K, inhibits apoptosis, demonstrating an important role of autophagy in dexamethasone-induced cell death. In this brief report, we review these findings and introduce the multiple myeloma cells as a novel system to study autophagy in response to dexamethasone.

PMID: 19855186 [PubMed - as supplied by publisher]

11-15-2009, 01:18 PM	#3
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Glucocorticoids Autophagy. 2009 Nov 18;5(8). [Epub ahead of print] Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. Grandér D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T. Department of Oncology/Pathology, Cancer Centre Karolinska (CCK) R8:03, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. We have recently shown that dexamethasone induces autophagy in lymphoid leukemia cells and in this particular setting this cell death modality is a prerequisite for the efficient killing of the leukemic cells by dexamethasone.(1) Hence, inhibition of autophagy by siRNA-mediated silencing of Beclin 1, as well as chemical inhibition of type III PtdIns3K, inhibits apoptosis, demonstrating an important role of autophagy in dexamethasone-induced cell death. In this brief report, we review these findings and introduce the multiple myeloma cells as a novel system to study autophagy in response to dexamethasone. PMID: 19855186 [PubMed - as supplied by publisher] __________________ Mom's treatment history (link)