[Laurel]

Update on some things that will inhibit one's ability to be accepted into this trial: you cannot be in a trial where DFS is the end point such as the SWOG trial with bisphosphonates. Furthermore, you may not be taking a bisphosphonate without a history of confirmed osteopenia or osteoporosis. In my case my insurance will pay for Fosamax without any authorization, and thus without the need for documented bone loss, however this will not fly with the Neratinib trial. You can exit the SWOG trial, have a washout period, and then enter the Neratinib trial. Likewise, if you are on a bisphosphonate prophalactically while on an A.I. to prevent bone loss, you will have to discontinue the bisphosphonate unless your bone density scan shows osteropenia or worse.

Always those irksome caveats with these trials! How do you roll the dice?????