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Old 10-17-2009, 05:45 PM   #17
Joan M
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Re: Progression in Lung Mets - Advice?

Courtney,

I'm sorry to hear about the progression in the lungs.

I've had a lung met which was removed by a wedge resection in 2007. It recurred a year later and I treated it with radiofrequency ablation (RFA). I also had a brain met treated by surgery and radiation. These procedures have allowed me to avoid chemo thus far, since the surgeries, RFA and radiation have made me NED each time. I've been taking only Herceptin since my bc advanced from stage IIb to IV.

Even though I did not have good look with the lung RFA, I still recommend checking it out. I know of other cases where there were no problems. In my case, a fungal ball (mycetoma or aspergilloma), from a common fungus that grows in the soil (aspergillus), grew in the cavity in my lung left by the RFA. But this was a rare occurrence, and the interventional radiation doc wants to do a case study on it.

The fungus eventually caused PET/CT scans to light up, and then I started coughing up blood. This lead to a thoracotomy for another wedge resection in July to stop the bleeding, and the surgery really knocked me on my butt. It was not like the minimally invasive lung surgery (VATS) I had the first time. I really met my match.

However, I was fortunate that there was no cancer, only the fungal ball. And now when I garden I'm supposed to wear a mask.

But, I'd do RFA again in the lung.

I also feel this way about RFA and cryoablation for the liver mets, even though that doesn't apply to me. If a bc patient doesn't have mets elsewhere, it makes sense to me not to stress the liver more by adding chemos that filter through the liver. It's like the liver enzymes are reacting to both the mets and the chemo.

Whichever treatment you choose, I hope it really zaps those mets.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!

Last edited by Joan M; 10-17-2009 at 05:48 PM..
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