HER2 Support Group Forums - View Single Post - Distinct inherited metastasis susceptibility exists for different bc subtypes

Hopeful · 10-14-2009, 06:18 AM

http://breast-cancer-research.com/co...df/bcr2412.pdf

"Conclusions:

These results validate SIPA1 and RRP1B as metastasis susceptibility genes and suggest that genotyping assays may be a useful supplement to other clinical and molecular indicators of prognosis. The results also suggest that lymphatic and hematogeneous metastases are genetically distinct that may involve different mechanisms. If true, these results suggest that metastatic disease, like primary breast cancer, may be multiple diseases and that stratification of late stage patients may therefore be required to fully understand breast cancer progression and metastasis."

Hopeful

10-14-2009, 06:18 AM	#1
Hopeful Senior Member Join Date: Aug 2006 Posts: 3,380	Distinct inherited metastasis susceptibility exists for different bc subtypes http://breast-cancer-research.com/co...df/bcr2412.pdf "Conclusions: These results validate SIPA1 and RRP1B as metastasis susceptibility genes and suggest that genotyping assays may be a useful supplement to other clinical and molecular indicators of prognosis. The results also suggest that lymphatic and hematogeneous metastases are genetically distinct that may involve different mechanisms. If true, *these results suggest that metastatic disease, like primary breast cancer, may be multiple diseases* and that stratification of late stage patients may therefore be required to fully understand breast cancer progression and metastasis." Hopeful